10/25/2023 0 Comments 11. tchia litman, ph.d.The identified IgD-ESTs only present membrane transcripts, with Cμ1 and five Cδ exons. It is different from that identified in Notothenioid teleost because it does not present the typical splicing pattern of membrane IgM. This is the first time that this short form of membrane IgM is described in a teleost. The IgM - ESTs corresponded with the secreted and membrane forms and surprisingly, the latter form only presented two constant heavy chain domains. ![]() We identified IgM and IgD coding ESTs, mainly in spleen, kidney and gills using published cDNA libraries but we did not find any sequence that coded for IgT or other heavy chain isotypes described in fish. ![]() The publication of whole genome sequences and the availability of several cDNA libraries for medaka ( Oryzias latipes) permitted us to perform a thorough analysis of immunoglobulin heavy chains present in this teleost. Bony fish present an immunological system, which evolved independently from those of animals that migrated to land 400 million years ago.
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